The mechanism of action (MoA) of SPIRIVA® Respimat®

160824 MoA Animation Website v1.5 JM

Acetylcholine in the airways and the role SPIRIVA®Respimat® (tiotropium) in asthma’ illustrates the mechanism of action (mode of action or MoA) of SPIRIVA® Respimat®, an inhaled long-acting anticholinergic medication, for the treatment of symptomatic asthma.

Asthma – the role of acetylcholine

Released from parasympathetic nerves, acetylcholine regulates bronchoconstriction and mucus secretion and clearance and is known to play a significant role in the pathophysiology of asthma.1,2 Acetylcholine modulates inflammation increases airway tone, contracts bronchial smooth muscle, and leads to mucus secretion and vasodilation. 1 The muscarinic M3 receptor is the primary subtype responsible for bronchial and tracheal smooth muscle contraction.2

How does SPIRIVA® Respimat® work in asthma?

SPIRIVA® Respimat® competitively and reversibly binds to M3 muscarinic receptors in bronchial smooth muscles antagonising the cholinergic (bronchoconstrictive) effects of acetylcholine, resulting in bronchial smooth muscle relaxation.3